Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome …

The matricellular protein osteopontin modulates cell–matrix interactions during tissue injury
and healing. A complex multidomain structure of osteopontin enables it not only to bind …

Aim This study aimed to investigate the causal impact of inflammatory cytokines on Sjogren's
Syndrome (SS) and to identify potential biomarkers for SS clinical management using …

Background Treatment of cardiovascular diseases (CVD) is a substantial burden to
healthcare systems worldwide. New tools are needed to improve precision of treatment by …

Heparin-induced thrombocytopenia (HIT) is an unpredictable, complex, immune-mediated
adverse drug reaction associated with a high mortality. Despite decades of research into …

Background The neutrophil-to-lymphocyte ratio (NLR) is the ratio between neutrophil and
lymphocyte counts measured in peripheral blood. NLR is easily calculable based on a …

Aims Several biomarkers are associated with clinical outcomes in patients with atrial
fibrillation (AF), but a causal relationship has not been established. This study aimed to …

Background Variations in circulatory cytokine levels have been observed during the onset
and course of palmoplantar pustulosis (PPP); however, whether these changes are due to …

Follicular lymphoma (FL), derived from germinal centre (GC) B cells, is a kind of systemic
neoplasm. Even though FL is indolent, it remains an incurable haematology Neoplasm …

Circulating proteins play key roles in inflammation and a broad range of diseases. To
identify genetic influences on inflammation-related proteins, we conducted a genome-wide …