ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

Potential drug–drug interactions mediated by the ATP-binding cassette (ABC) transporter
and solute carrier (SLC) transporter families are of clinical and regulatory concern. However …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production
or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to …

The importance of drug transporters as one of the determinants of pharmacokinetics has
become increasingly evident [1]. While much research has been conducted focusing the role …

Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …

Inherited disorders of bilirubin metabolism might reduce bilirubin uptake by hepatocytes,
bilirubin conjugation, or secretion of bilirubin into bile. Reductions in uptake could increase …

Recently, the US Food and Drug Administration and European Medicines Agency have
issued new guidance for industry on drug interaction studies, which outline comprehensive …

Abstract The IL-17A producing T-helper-17 (Th17) cell population plays a major role in
rheumatoid arthritis (RA) pathogenesis and has gained wide interest as treatment target. IL …