Targeting ROS in cancer: rationale and strategies

C Glorieux, S Liu, D Trachootham… - Nature Reviews Drug …, 2024 - nature.com
Reactive oxygen species (ROS) in biological systems are transient but essential molecules
that are generated and eliminated by a complex set of delicately balanced molecular …

Recent advancements in the targeted delivery of etoposide nanomedicine for cancer therapy: A comprehensive review

S Fathi-Karkan, R Arshad, A Rahdar… - European Journal of …, 2023 - Elsevier
Etoposide (ETO), a popular anticancer drug that inhibits topoisomerase II enzymes, may be
administered more effectively and efficiently due to nanomedicine. The therapeutic …

Recent insights into nanotechnology in colorectal cancer

AAZ Dezfuli, M Abu-Elghait, SS Salem - Applied Biochemistry and …, 2024 - Springer
Colorectal cancer (CRC) is the third cancer among the known causes of cancer that impact
people. Although CRC drug options are imperfect, primary detection of CRC can play a key …

Naturally and chemically acetylated polysaccharides: Structural characteristics, synthesis, activities, and applications in the delivery system: A review

H Li, Y Wang, P Zhao, L Guo, L Huang, X Li… - Carbohydrate Polymers, 2023 - Elsevier
Acetylated polysaccharides refer to polysaccharides containing acetyl groups on sugar
units. In the past, the acetylation modification of wall polysaccharides has been a hot …

A review of chitosan in gene therapy: developments and challenges

L Dong, Y Li, H Cong, B Yu, Y Shen - Carbohydrate Polymers, 2024 - Elsevier
Gene therapy, as a revolutionary treatment, has been gaining more and more attention. The
key to gene therapy is the selection of suitable vectors for protection of exogenous nucleic …

Hyaluronic acid-based prodrug nanomedicines for enhanced tumor targeting and therapy: A review

R Zhang, X Zhao, A Jia, C Wang, H Jiang - International Journal of …, 2023 - Elsevier
Hyaluronic acid (HA) represents a natural polysaccharide which has attracted significant
attention owing to its improved tumor targeting capacity, enzyme degradation capacity, and …

Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy

Z Luo, Y Huang, N Batra, Y Chen, H Huang… - Nature …, 2024 - nature.com
The multifaceted chemo-immune resistance is the principal barrier to achieving cure in
cancer patients. Identifying a target that is critically involved in chemo-immune-resistance …

Nano-sized fucoidan interpolyelectrolyte complexes: Recent advances in design and prospects for biomedical applications

NV Dubashynskaya, ER Gasilova… - International Journal of …, 2023 - mdpi.com
The marine polysaccharide fucoidan (FUC) is a promising polymer for pharmaceutical
research and development of novel drug delivery systems with modified release and …

Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma

K Kousar, F Naseer, MS Abduh, S Kakar… - Frontiers in …, 2023 - frontiersin.org
Cervical carcinoma is one of the most prevalent gynecological cancers throughout the world.
Cisplatin is used as first line chemotherapy for treatment of cervical cancer, but it comes with …

Engineered mesoporous silica nanoparticles, new insight nanoplatforms into effective cancer gene therapy

R Heidari, V Assadollahi, P Khosravian… - International Journal of …, 2023 - Elsevier
The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …