Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

A systematic literature review was undertaken to determine if conditioned pain modulation
(CPM) is reliable. Longitudinal, English language observational studies of the repeatability …

Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …

There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

Abstract Development and application of psychophysical test paradigms to assess
endogenous pain modulation in healthy controls and in patients yielded large body of data …

The gabapentinoid drugs gabapentin and pregabalin are key front‐line therapies for various
neuropathies of peripheral and central origin. Originally designed as analogs of GABA, the …

Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the
descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect …

Objective: To systematically assess the effect of pharmacologic treatments of diabetic
peripheral neuropathy (DPN) on pain and quality of life. Methods: We searched PubMed …

Descending controls, comprising pathways that originate in midbrain and brainstem regions
and project onto the spinal cord, have long been recognised as key links in the multiple …

Musculoskeletal pain disorders are the second largest contributor to global disability
underlining the significance of effective treatments. However, treating chronic …