Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Insulin, a small protein with 51 amino acids synthesized by pancreatic β-cells, is crucial to
sustain glucose homeostasis at biochemical and molecular levels. Numerous metabolic …

The evolutionarily-conserved Notch signaling pathway plays critical roles in cell
communication, function and homeostasis equilibrium. The pathway serves as a cell-to-cell …

Multiple myeloma (MM) is the most common cause of death from hematological malignancy
worldwide, and recent studies have revealed that let-7b-5p can play an inhibitory role in …

Non‐small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor
(EGFR) mutation have benefited from treatment of reversible EGFR tyrosine kinase inhibitors …

Although important progress has been made in elucidating the role of the tumor
microenvironment in the development of bladder cancer, little is currently known regarding …

Background: Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor
receptor (EGFR) mutation often initially respond to EGFR tyrosine kinase inhibitor (EGFR …

Checkpoint blockade therapy has been proven efficacious in lung cancer patients. However,
primary/acquired resistance hampers its efficacy. Therefore, there is an urgent need to …

Background A new histological classification by the International Association for the Study of
Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) …

The insulin-like growth factor-1 (IGF-1) signaling pathway has been implicated in non-small
cell lung cancer (NSCLC) outcomes and resistance to targeted therapies. However, little is …