The neuromuscular junction in health and disease: molecular mechanisms governing synaptic formation and homeostasis

PM Rodríguez Cruz, J Cossins, D Beeson… - Frontiers in molecular …, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Neuromuscular junction formation, aging, and disorders

L Li, WC Xiong, L Mei - Annual review of physiology, 2018 - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

To build a synapse: signaling pathways in neuromuscular junction assembly

H Wu, WC Xiong, L Mei - Development, 2010 - journals.biologists.com
Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Control of synapse development and plasticity by Rho GTPase regulatory proteins

KF Tolias, JG Duman, K Um - Progress in neurobiology, 2011 - Elsevier
Synapses are specialized cell–cell contacts that mediate communication between neurons.
Most excitatory synapses in the brain are housed on dendritic spines, small actin-rich …

Molecular mechanisms underlying maturation and maintenance of the vertebrate neuromuscular junction

L Shi, AKY Fu, NY Ip - Trends in neurosciences, 2012 - cell.com
The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between
motoneuron and skeletal muscle, is characterized by a protracted postnatal period of …

Homeostatic plasticity at the Drosophila neuromuscular junction

CA Frank - Neuropharmacology, 2014 - Elsevier
In biology, homeostasis refers to how cells maintain appropriate levels of activity. This
concept underlies a balancing act in the nervous system. Synapses require flexibility (ie …

Interactions between EGFR and EphA2 promote tumorigenesis through the action of Ephexin1

J Kim, IY Chang, HJ You - Cell Death & Disease, 2022 - nature.com
The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and
colorectal cancer and play an important role in tumorigenesis. Although the respective …

Secreted signaling molecules at the neuromuscular junction in physiology and pathology

B Ohkawara, M Ito, K Ohno - International Journal of Molecular Sciences, 2021 - mdpi.com
Signal transduction at the neuromuscular junction (NMJ) is affected in many human
diseases, including congenital myasthenic syndromes (CMS), myasthenia gravis, Lambert …

[HTML][HTML] Human motor endplate remodeling after traumatic nerve injury

R Gupta, JP Chan, J Uong, WA Palispis… - Journal of …, 2020 - thejns.org
OBJECTIVE Current management of traumatic peripheral nerve injuries is variable with
operative decisions based on assumptions that irreversible degeneration of the human …

Role of nucleosome remodeling in neurodevelopmental and intellectual disability disorders

AJ López, MA Wood - Frontiers in behavioral neuroscience, 2015 - frontiersin.org
It is becoming increasingly important to understand how epigenetic mechanisms control
gene expression during neurodevelopment. Two epigenetic mechanisms that have received …