In response to the energy demand triggered by developmental signals and environmental
stressors, the cells launch the mitochondrial biogenesis process. This is a self‐renewal …

Aging is a general degenerative process related to deterioration of cell functions in the entire
organism. Mitochondria, which play a key role in energy homeostasis and metabolism of …

Mitochondria are organelles with a highly dynamic ultrastructure maintained by a delicate
equilibrium between its fission and fusion rates. Understanding the factors influencing this …

Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

There is substantial and promising evidence on the health benefits of consuming broccoli
and other cruciferous vegetables. The most important compound in broccoli, glucoraphanin …

Mitochondria play essential roles in cellular bioenergetics, biosynthesis, and apoptosis.
During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …

The nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also called Nfe2l2) and its
cytoplasmic repressor, Kelch-like ECH-associated protein 1 (KEAP1), are major regulators …

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

Understanding of molecular mechanisms of tumor growth has an increasing impact on the
development of diagnostics and targeted therapy of human neoplasia. In this review, we …

Cancer is one of the major causes of morbidity and mortality in the world. Carcinogenesis is
a multistep process induced by genetic and epigenetic changes that disrupt pathways …