Bcl11 transcription factors regulate cortical development and function
R Simon, C Wiegreffe, S Britsch - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Transcription factors regulate multiple processes during brain development and in the adult
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …
brain, from brain patterning to differentiation and maturation of highly specialized neurons as …
TLX: A master regulator for neural stem cell maintenance and neurogenesis
The orphan nuclear receptor TLX, also known as NR2E1, is an essential regulator of neural
stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is …
stem cell (NSC) self-renewal, maintenance, and neurogenesis. In vertebrates, TLX is …
A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA
Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …
Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders
SB Estruch, SA Graham, M Quevedo… - Human molecular …, 2018 - academic.oup.com
FOXP transcription factors play important roles in neurodevelopment, but little is known
about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate …
about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate …
In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling
STUDY QUESTION How does maternal cigarette smoking disturb development of the
human fetal ovary? SUMMARY ANSWER Maternal smoking increases fetal estrogen titres …
human fetal ovary? SUMMARY ANSWER Maternal smoking increases fetal estrogen titres …
Characterization of the TBR1 interactome: variants associated with neurodevelopmental disorders disrupt novel protein interactions
E Sollis, J Den Hoed, M Quevedo… - Human Molecular …, 2023 - academic.oup.com
TBR1 is a neuron-specific transcription factor involved in brain development and implicated
in a neurodevelopmental disorder (NDD) combining features of autism spectrum disorder …
in a neurodevelopmental disorder (NDD) combining features of autism spectrum disorder …
Functional characterization of TBR1 variants in neurodevelopmental disorder
Recurrent de novo variants in the TBR1 transcription factor are implicated in the etiology of
sporadic autism spectrum disorders (ASD). Disruptions include missense variants located in …
sporadic autism spectrum disorders (ASD). Disruptions include missense variants located in …
Transcription factors Bcl11a and Bcl11b are required for the production and differentiation of cortical projection neurons
The generation and differentiation of cortical projection neurons are extensively regulated by
interactive programs of transcriptional factors. Here, we report the cooperative functions of …
interactive programs of transcriptional factors. Here, we report the cooperative functions of …
Nuclear receptor TLX in development and diseases
The nuclear receptor TLX (NR2E1) is a transcription factor that is critical for neural
development and adult neurogenesis through its actions in regulating neural stem cell …
development and adult neurogenesis through its actions in regulating neural stem cell …
Predicting puberty in partial androgen insensitivity syndrome: Use of clinical and functional androgen receptor indices
N Lek, R Tadokoro-Cuccaro, JB Whitchurch… - …, 2018 - thelancet.com
Background PAIS exhibits a complex spectrum of phenotypes and pubertal outcomes. The
paucity of reliable prognostic indicators can confound management decisions including sex …
paucity of reliable prognostic indicators can confound management decisions including sex …