The language of genes

DB Searls - Nature, 2002 - nature.com
Linguistic metaphors have been woven into the fabric of molecular biology since its
inception. The determination of the human genome sequence has brought these metaphors …

[图书][B] Biological sequence analysis: probabilistic models of proteins and nucleic acids

R Durbin, SR Eddy, A Krogh, G Mitchison - 1998 - books.google.com
Probabilistic models are becoming increasingly important in analysing the huge amount of
data being produced by large-scale DNA-sequencing efforts such as the Human Genome …

A dynamic programming algorithm for RNA structure prediction including pseudoknots

E Rivas, SR Eddy - Journal of molecular biology, 1999 - Elsevier
We describe a dynamic programming algorithm for predicting optimal RNA secondary
structure, including pseudoknots. The algorithm has a worst case complexity of O (N6) in …

RNA pseudoknot prediction in energy-based models

RB Lyngsø, CNS Pedersen - Journal of computational biology, 2000 - liebertpub.com
RNA molecules are sequences of nucleotides that serve as more than mere intermediaries
between DNA and proteins, eg, as catalytic molecules. Computational prediction of RNA …

[HTML][HTML] Dynamic programming algorithms for RNA secondary structure prediction with pseudoknots

T Akutsu - Discrete Applied Mathematics, 2000 - Elsevier
This paper shows simple dynamic programming algorithms for RNA secondary structure
prediction with pseudoknots. For a basic version of the problem (ie, maximizing the number …

Computational methods in noncoding RNA research

A Machado-Lima, HA Del Portillo… - Journal of mathematical …, 2008 - Springer
Non protein-coding RNAs (ncRNAs) are a research hotspot in bioinformatics. Recent
discoveries have revealed new ncRNA families performing a variety of roles, from gene …

The language of RNA: a formal grammar that includes pseudoknots

E Rivas, SR Eddy - Bioinformatics, 2000 - academic.oup.com
Motivation: In a previous paper, we presented a polynomial time dynamic programming
algorithm for predicting optimal RNA secondary structure including pseudoknots. However …

Tree adjoining grammars for RNA structure prediction

Y Uemura, A Hasegawa, S Kobayashi… - Theoretical computer …, 1999 - Elsevier
In this paper, we are concerned with identifying a subclass of tree adjoining grammars
(TAGs) that is suitable for the application to modeling and predicting RNA secondary …

[图书][B] Algorithms in bioinformatics: A practical introduction

WK Sung - 2009 - taylorfrancis.com
Thoroughly Describes Biological Applications, Computational Problems, and Various
Algorithmic Solutions Developed from the author's own teaching material, Algorithms in …

[HTML][HTML] Accelerated probabilistic inference of RNA structure evolution

I Holmes - BMC bioinformatics, 2005 - Springer
Background Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for
evolutionary analysis of RNA, including simultaneous RNA sequence alignment and …