Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease

MB Boffa, ML Koschinsky - Nature Reviews Cardiology, 2019 - nature.com
Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Existing and emerging strategies to lower Lipoprotein (a)

GG Schwartz, CM Ballantyne - Atherosclerosis, 2022 - Elsevier
Abundant evidence links elevated levels of lipoprotein (a)(Lp (a)) to higher cardiovascular
risk, leaving clinicians with the challenge of what measures to take to mitigate Lp (a) …

Genomic targets of nuclear estrogen receptors

R O'Lone, MC Frith, EK Karlsson… - Molecular …, 2004 - academic.oup.com
Estrogen influences the physiology of many target tissues in both women and men. The long-
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …

Oxidized phospholipids in cardiovascular disease

S Tsimikas, JL Witztum - Nature Reviews Cardiology, 2024 - nature.com
Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic
inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma …

Lipoprotein (a) metabolism: potential sites for therapeutic targets

J Hoover-Plow, M Huang - Metabolism, 2013 - Elsevier
Lipoprotein (a)[Lp (a)] resembles low-density lipoprotein (LDL), with an LDL lipid core and
apolipoprotein B (apoB), but contains a unique apolipoprotein, apo (a). Elevated Lp (a) is an …

The effect of menopause on lipoprotein (a) concentrations: A systematic review and meta-analysis

P Anagnostis, C Antza, C Trakatelli, I Lambrinoudaki… - Maturitas, 2023 - Elsevier
Objective Transition to menopause has been associated with an increased risk of
cardiovascular disease (CVD), attributed mainly to atherogenic dyslipidemia. Whether …

The renaissance of lipoprotein (a): brave new world for preventive cardiology?

KL Ellis, MB Boffa, A Sahebkar, ML Koschinsky… - Progress in Lipid …, 2017 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a highly heritable cardiovascular risk factor. Although
discovered more than 50 years ago, Lp (a) has recently re-emerged as a major focus in the …

Signal cross-talk between estrogen receptor alpha and beta and the peroxisome proliferator-activated receptor gamma1 in MDA-MB-231 and MCF-7 breast cancer …

X Wang, MW Kilgore - Molecular and cellular endocrinology, 2002 - Elsevier
We have previously demonstrated that peroxisome proliferator-activated receptor gamma
(PPARγ) is expressed and transcriptionally responsive to both synthetic and natural ligands …

The effect of hormone replacement therapy and tibolone on lipoprotein (a) concentrations in postmenopausal women: a systematic review and meta-analysis

P Anagnostis, P Galanis, V Chatzistergiou… - Maturitas, 2017 - Elsevier
Objective Data on the effect of hormone replacement therapy (HRT) and tibolone on
lipoprotein (a)[Lp (a)], an independent risk factor for cardiovascular disease, are …

Effects of Lipid-Modifying and Other Drugs on Lipoprotein (a) Levels—Potent Clinical Implications

AD Koutsogianni, G Liamis, E Liberopoulos… - Pharmaceuticals, 2023 - mdpi.com
The past few years have shown an ongoing interest in lipoprotein (a)(Lp (a)), a lipid
molecule that has been proven to have atherogenic, thrombogenic, and inflammatory …