Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Pyramidal neurons are characterized by their distinct apical and basal dendritic trees and
the pyramidal shape of their soma. They are found in several regions of the CNS and …

Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to
adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Hippocampal CA1 pyramidal neurons have frequently been regarded as a homogeneous
cell population in biophysical, pharmacological and modeling studies. We found robust …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Strengthening of synaptic connections following coincident pre-and postsynaptic activity was
proposed by Hebb as a cellular mechanism for learning. Contemporary models assume that …

Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to
be homogeneous in their somatodendritic morphology and physiology. Recent work using …

The fundamental building block of every nervous system is the single neuron.
Understanding how these exquisitely structured elements operate is an integral part of the …

Dendritic spines are the nearly ubiquitous site of excitatory synaptic input onto neurons, and
as such are critically positioned to influence diverse aspects of neuronal signalling. Decades …