The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Role of insulin resistance in MAFLD

Y Sakurai, N Kubota, T Yamauchi… - International journal of …, 2021 - mdpi.com
Many studies have reported that metabolic dysfunction is closely involved in the complex
mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which …

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes

R Wagner, M Heni, AG Tabak, J Machann, F Schick… - Nature medicine, 2021 - nature.com
The state of intermediate hyperglycemia is indicative of elevated risk of developing type 2
diabetes. However, the current definition of prediabetes neither reflects subphenotypes of …

Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial

XT Teong, K Liu, AD Vincent, J Bensalem, B Liu… - Nature Medicine, 2023 - nature.com
Intermittent fasting appears an equivalent alternative to calorie restriction (CR) to improve
health in humans. However, few trials have considered applying meal timing during the …

[HTML][HTML] Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake

KD Hall, A Ayuketah, R Brychta, H Cai, T Cassimatis… - Cell metabolism, 2019 - cell.com
We investigated whether ultra-processed foods affect energy intake in 20 weight-stable
adults, aged (mean±SE) 31.2±1.6 years and BMI= 27±1.5 kg/m 2. Subjects were admitted to …

Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

HF Escobar-Morreale - Nature Reviews Endocrinology, 2018 - nature.com
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic
disorders in premenopausal women. Heterogeneous by nature, PCOS is defined by a …

Metabolically healthy obesity: facts and fantasies

GI Smith, B Mittendorfer, S Klein - The Journal of clinical …, 2019 - Am Soc Clin Investig
Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …

Light exposure during sleep impairs cardiometabolic function

IC Mason, D Grimaldi, KJ Reid… - Proceedings of the …, 2022 - National Acad Sciences
This study tested the hypothesis that acute exposure to light during nighttime sleep
adversely affects next-morning glucose homeostasis and whether this effect occurs via …

[HTML][HTML] Assessment of insulin secretion and insulin resistance in human

SY Park, JF Gautier, S Chon - Diabetes & metabolism …, 2021 - synapse.koreamed.org
The impaired insulin secretion and increased insulin resistance (or decreased insulin
sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is …

A longitudinal big data approach for precision health

SM Schüssler-Fiorenza Rose, K Contrepois… - Nature medicine, 2019 - nature.com
Precision health relies on the ability to assess disease risk at an individual level, detect early
preclinical conditions and initiate preventive strategies. Recent technological advances in …