Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest
tissues of the sympathetic nervous system. NB is highly heterogeneous both from a clinical …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

Peripheral neuroblastic tumors (PNTs) represent a spectrum of neural-crest-derived tumors,
including neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Malignant cells in …

Epithelial-to-mesenchymal transition (EMT) represents conversion of an epithelial cell in an
elongated cell with mesenchymal phenotype, which can occur in physiologic and pathologic …

High-risk neuroblastomas typically display an undifferentiated or poorly differentiated
morphology. It is therefore vital to understand molecular mechanisms that block the …

Neuroblastoma (NB) is the most common cancer of infancy and accounts for nearly one
tenth of pediatric cancer deaths. This mortality rate has been attributed to the> 50 …

Background Neuroblastoma (NB) is a devastating disease. Despite recent advances in the
treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event …

Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …

Background Intrinsic and extrinsic factors in the tumour microenvironment (TME) contribute
to therapeutic resistance. Here we demonstrate that transforming growth factor (TGF)-β1 …

Metastatic dissemination of tumor cells represents a major obstacle towards cancer cure.
Tumor cells with metastatic capacity are often resistant to chemotherapy. Experimental …