The cell cycle is the series of events that occur in a cell leading to its division and
duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the …

Cancer is the second leading cause of death worldwide, and despite the effort of standard
treatments, the search for new tools against this disease is necessary. Importantly, it is …

The toxicity of Orellanine (OR), a significant factor in mushroom poisoning, has severe
effects on the kidneys, particularly the proximal tubules. This study investigated the acute …

The present study reports the one-step synthesis of several 3-formyl-4-hydroxycouramin-
derived enamines (4a–4i) in good yields (65–94%). The characterization of the synthesized …

The hematopoietic system is susceptible to ionizing radiation (IR), which can cause acute
hematopoietic failure or long-term myelosuppression. As the most primitive cells of the …

Cancer remains a major global health challenge, prompting the search for effective and less
toxic treatments. Anethole, a bioactive compound found in essential oils of anise and fennel …

Protein kinases have essential responsibilities in controlling several cellular processes, and
their abnormal regulation is strongly related to the development of cancer. The …

Targeted protein degradation has emerged as a powerful approach for the selective
elimination of disease-causing proteins. Cyclin-dependent kinases 4 and 6 (CDK4/6) are of …

Cyclin-dependent kinases (CDKs) constitute a vital family of protein-serine kinases, pivotal
in regulating various cellular processes such as the cell cycle, metabolism, proteolysis, and …

NMDA receptors are Ca 2+-permeable ligand-gated ion channels that mediate fast
excitatory transmission in the central nervous system. NMDA receptors regulate the …