Abstract Purpose: OATP1B1 (SLCO1B1) is the most abundant and pharmacologically
relevant uptake transporter in the liver and a key mediator of xenobiotic clearance. However …

The organic anion transporting polypeptide (OATP) 2B1 is localized on the basolateral
membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern …

In this study, konjac glucomannan (KGM) and its derivatives were gavaged as dietary fiber
supplements, followed by a single dose of antibiotic cocktail (Abx) containing amoxicillin …

The addition of darolutamide, an androgen receptor signalling inhibitor, to therapy with
docetaxel has recently been approved as a strategy to treat metastatic prostate cancer …

The membrane transport of many cationic prescription drugs depends on facilitated transport
by organic cation transporters of which several members, including OCT2 (SLC22A2), are …

The Guide for the Care and Use of Laboratory Animals strongly encourages the use of
pharmaceutical-grade chemicals and analgesics. Sustained-release buprenorphine (SRB) …

Dofetilide is a rapid delayed rectifier potassium current inhibitor widely used to prevent the
recurrence of atrial fibrillation and flutter. The clinical use of this drug is associated with …

Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and
subsequent elimination of diverse cationic compounds. Although OCT1 has been involved …

Venetoclax, a BCL-2 inhibitor used to treat certain hematological cancers, exhibits low oral
bioavailability and high interpatient pharmacokinetic variability. Venetoclax is commonly …

Gilteritinib, an FDA-approved tyrosine kinase inhibitor approved for the treatment of
relapsed/refractory FLT3-mutated acute myeloid leukemia, is primarily eliminated via …