Endoplasmic reticulum (ER) stress is a major contributor to liver disease and hepatic
fibrosis, but the role it plays varies depending on the cause and progression of the disease …

Technological advances now enable routine measurement of mRNA and protein
abundances, and estimates of their rates of synthesis and degradation that inform on their …

The relative importance of regulation at the mRNA versus protein level is subject to ongoing
debate. To address this question in a dynamic system, we mapped proteomic and …

Heat stress is one of the most prominent and deleterious environmental threats affecting
plant growth and development. Upon high temperatures, plants launch specialized gene …

Protein concentrations evolve under greater evolutionary constraint than mRNA levels.
Translation efficiency of mRNA represents the chief determinant of basal protein …

Responsible for generating the proteome that controls phenotype, translation is the ultimate
convergence point for myriad upstream signals that influence gene expression. System …

Maintaining a healthy proteome involves all layers of gene expression regulation. By
quantifying temporal changes of the transcriptome, translatome, proteome, and RNA-protein …

The mammalian unfolded protein response (UPR) is propagated by three ER-resident
transmembrane proteins, each of which initiates a signaling cascade that ultimately …

Diabetic kidney disease is the leading worldwide cause of end stage kidney disease and a
growing public health challenge. The diabetic kidney is exposed to many environmental …

Autism spectrum disorder (ASD) has a strong and complex genetic component with an
estimate of more than 1000 genes implicated cataloged in SFARI (Simon′ s Foundation …