Members of the Rab or ARF/Sar branches of the Ras GTPase superfamily regulate almost
every step of intracellular membrane traffic. A rapidly growing body of evidence indicates …

The fundamental separation of Golgi function between subcompartments termed cisternae is
conserved across all eukaryotes. Likewise, Rab proteins, small GTPases of the Ras …

Type IV P-type ATPases (P4-ATPases) are putative phospholipid flippases that translocate
phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers and …

The Arp2/3-activator Wiskott–Aldrich syndrome protein and Scar homologue (WASH) is
suggested to regulate actin-dependent membrane scission during endosomal sorting, but its …

The GTPases of the Ras superfamily regulate cell growth, membrane traffic and the
cytoskeleton, and a wide range of diseases are caused by mutations in particular members …

We showed previously that ATP11A and ATP11C have flippase activity toward
aminophospholipids (phosphatidylserine (PS) and phosphatidylethanolamine (PE)) and …

Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and
migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate Rab GDP-GTP …

Arl8b, an Arf-like GTP-binding protein, regulates cargo trafficking and positioning of
lysosomes. However, it is unknown whether Arl8b regulates lysosomal cargo sorting. Here …

Membrane traffic operates by vesicles that bud from precursor organelles and are
transported to their target compartment where they dock and fuse. Targeting requires …

The matrix metalloproteinase MT1-MMP has a major impact on invasive cell migration in
both physiological and pathological settings such as immune cell extravasation or …