Advanced drug delivery and therapeutic strategies for tuberculosis treatment

A Nair, A Greeny, A Nandan, RK Sah, A Jose… - Journal of …, 2023 - Springer
Tuberculosis (TB) remains a significant global health challenge, necessitating innovative
approaches for effective treatment. Conventional TB therapy encounters several limitations …

[HTML][HTML] Long-term application of organic fertilizer prompting the dispersal of antibiotic resistance genes and their health risks in the soil plastisphere

D Lin, JY Xu, L Wang, S Du, D Zhu - Environment International, 2024 - Elsevier
Microplastic (MP) pollution is a rapidly growing global environmental concern that has led to
the emergence of a new environmental compartment, the plastisphere, which is a hotspot for …

LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase

J Zeng, C Xie, Z Huang, CH Cho, H Chan, Q Li… - Nature …, 2024 - nature.com
The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection
is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A …

The molecular basis and downstream immune consequences of mycobacteria–host cell interactions

W Daher, V Pichler, J Karam… - FEMS Microbiology …, 2023 - academic.oup.com
Pathogenic mycobacteria gain entry to their hosts by inhalation or ingestion where they
adhere to different cell types and are subsequently internalized by professional phagocytic …

Identification of a PD1/PD‐L1 inhibitor by structure‐based pharmacophore modelling, virtual screening, molecular docking and biological evaluation

A Choorakottayil Pushkaran, KK, R Biswas… - Molecular …, 2023 - Wiley Online Library
Abstract PD‐1/PD‐L1 is a critical druggable target for immunotherapy against sepsis.
Chemoinformatics techniques involved the structure‐based 3D pharmacophore model …

Efficacy of Lysostaphin functionalized silicon catheter for the prevention of Staphylococcus aureus biofilm

J Jayakumar, V Vinod, T Arumugam, BN Sathy… - International Journal of …, 2024 - Elsevier
Staphylococcus aureus readily forms biofilms on tissue and indwelling catheter surfaces.
These biofilms are resistant to antibiotics. Consequently, effective prevention and treatment …

Construction of subunit-based DNA vaccines against tuberculosis using five different Mycobacterium specific genes

MM Zaman, MI Shahzad, A Jilani, A Yousaf… - Advancements in Life …, 2024 - als-journal.com
Background: Tuberculosis remains the major infectious and contagious disease with respect
to morbidity and mortality around the globe. The main etiological agent of TB is …

[图书][B] Development of a hybrid BCG: Cathepsin B vaccination strategy against Schistosoma mansoni infection

E Mouhoub - 2023 - search.proquest.com
Schistosomiasis is a human helminth infection of significant importance due to its extensive
global prevalence, and severe impact on quality of life. Well above 250 million individuals …

Molecular Cloning and Functional Interaction by Computational Analysis

M Abinaya, B Vaseeharan - Aquatic Lectins: Immune Defense, Biological …, 2022 - Springer
Crustacean lectins are pattern recognition proteins which are deficient in an adaptive
immune system and solely on their innate immunity. Insights into molecular level of lectin …

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

JJ Joseph - 2022 - ir.library.oregonstate.edu
To examine the macrophage response to M. avium, I compared inflammasome and cytosolic
sensor expression and activation. My result demonstrated that virulent strains of M. avium …