Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA
replication errors. The fundamental mechanisms and proteins involved in the early reactions …

The genome of all organisms is constantly being challenged by endogenous and
exogenous sources of DNA damage. Errors like base: base mismatches or small insertions …

DNA-binding proteins survey genomes for targets using facilitated diffusion, which typically
includes a one-dimensional (1D) scanning component for sampling local regions …

Crossing over between homologous chromosomes is initiated in meiotic prophase in most
sexually reproducing organisms by the appearance of programmed double strand breaks …

The mismatch repair (MMR) family complexes Msh4-Msh5 and Mlh1-Mlh3 act with Exo1 and
Sgs1-Top3-Rmi1 in a meiotic double strand break repair pathway that results in the …

The machinery of DNA mismatch repair enzymes is highly conserved in evolution. The
process is initiated by recognition of a DNA mismatch, and validated by ATP and the …

DNA mismatch repair corrects errors that have escaped polymerase proofreading,
increasing replication fidelity 100-to 1000-fold in organisms ranging from bacteria to …

MutLα, the heterodimeric eukaryotic MutL homolog, is required for DNA mismatch repair
(MMR) in vivo. It has been suggested that conformational changes, modulated by adenine …

The functional characterization of nonsynonymous single nucleotide polymorphisms in
human mismatch repair (MMR) genes has been critical to evaluate their pathogenicity for …