An increasing recognition has emerged of the complexities of the global health agenda—
specifically, the collision of infections and noncommunicable diseases and the dual burden …

The epigenetic phenomena refer to heritable changes in gene expression other than those
in the DNA sequence, such as DNA methylation and histone modifications. Major research …

Background Abnormal epigenetic marking is well documented in gene promoters of cancer
cells, but the study of distal regulatory siteshas lagged behind. We performed a systematic …

Cell‐selective glucocorticoid receptor (GR) binding to distal regulatory elements is
associated with cell type‐specific regions of locally accessible chromatin. These regions can …

The complex relationship between DNA methylation, chromatin modification, and underlying
DNA sequence is often difficult to unravel with existing technologies. Here, we describe a …

Cancer is being reinterpreted in the light of recent discoveries related to the histone code
and the dynamic nature of epigenetic regulation and control of gene programs during …

Complex molecular mechanisms define our responses to environmental stimuli. Beyond the
DNA sequence itself, epigenetic machinery orchestrates changes in gene expression …

Enhancers are a class of cis-regulatory elements that can increase gene transcription by
forming loops in intergenic regions, introns and exons. Enhancers, as well as their …

Mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) lead to disrupted
neuronal function and can cause the neurodevelopmental disorder Rett syndrome. MeCP2 …

We report that homology-directed repair of a DNA double-strand break within a single copy
Green Fluorescent Protein (GFP) gene in HeLa cells alters the methylation pattern at the site …