Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Antimalarial drug resistance: a threat to malaria elimination
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
Antimalarial drug resistance in Africa: the calm before the storm?
MD Conrad, PJ Rosenthal - The Lancet Infectious Diseases, 2019 - thelancet.com
Antimalarial drug resistance, in particular resistance to Plasmodium falciparum, challenges
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
the treatment and control of malaria. In this Review, we summarise evolving patterns of …
[HTML][HTML] Antimalarial drug resistance: literature review and activities and findings of the ICEMR network
L Cui, S Mharakurwa, D Ndiaye… - The American journal …, 2015 - ncbi.nlm.nih.gov
Antimalarial drugs are key tools for the control and elimination of malaria. Recent decreases
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …
in the global malaria burden are likely due, in part, to the deployment of artemisinin-based …
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine
The widely used antimalarial combination therapy dihydroartemisinin+ piperaquine (DHA+
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
PPQ) has failed in Cambodia. Here, we perform a genomic analysis that reveals a rapid …
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …
(ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites …
Antimalarial drug resistance: an overview
HA Antony, SC Parija - Tropical parasitology, 2016 - journals.lww.com
Malaria is a major public health burden throughout the world. Resistance to the antimalarial
drugs has increased the mortality and morbidity rate that is achieved so far through the …
drugs has increased the mortality and morbidity rate that is achieved so far through the …
PfCRT and its role in antimalarial drug resistance
Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …
Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …
continues to afflict hundreds of millions of people every year. Infections with malaria …
[HTML][HTML] Drug-resistant malaria: molecular mechanisms and implications for public health
Resistance to antimalarial drugs has often threatened malaria elimination efforts and
historically has led to the short-term resurgence of malaria incidences and deaths. With …
historically has led to the short-term resurgence of malaria incidences and deaths. With …