The conundrum of modality selection in clinical diagnostic imaging is that modalities with the
highest sensitivity have relatively poor resolution, while those with high resolution have …

Pharmaceutical industry is constantly looking for ways to ensure and enhance product
safety, quality and efficacy. However, drug recalls, manufacturing failure cost, scale up …

Currently, the use of alternative solvents is increasing, namely ionic liquids (ILs) and deep
eutectic solvents (DESs) in diverse fields of knowledge, such as biochemistry, chemistry …

The detection of doping with MIRCERA (the brand name for Continuous Erythropoietin
Receptor Activator, or CERA) is hampered by the limited excretion of the rather large …

H4octox, a versatile new octadentate acyclic chelating ligand, has been investigated as an
alternative to the acyclic DTPA and the macrocyclic DOTA for trivalent metal ions useful in …

Polyethylenimine (PEI) has been widely used as a transfection agent for gene delivery, but it
is cytotoxic and can lead to cell apoptosis. Although several apoptotic mechanisms have …

This investigation evaluated the utility of a physiologically based pharmacokinetic (PBPK)
model, which incorporates model parameters representing key determinants of monoclonal …

A capillary sodium dodecyl sulfate gel electrophoresis (cSDS) method has been developed
and qualified for purity and impurity analysis of monoclonal antibodies. This method was …

Optical super-resolution microscopy techniques enable high molecular specificity with high
spatial resolution and constitute a set of powerful tools in the investigation of the structure of …

Since gene therapy started over 20 years ago, more than one-thousand clinical trials have
been carried out. Nonviral vectors present interesting properties for their clinical application …