Globally, there is a huge unmet need for effective treatments for neurodegenerative
diseases. The complexity of the molecular mechanisms underlying neuronal degeneration …

Cognitive ageing research examines the cognitive abilities that are preserved and/or those
that decline with advanced age. There is great individual variability in cognitive ageing …

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

Background Genome-wide association studies (GWAS) in Parkinson's disease have
increased the scope of biological knowledge about the disease over the past decade. We …

The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …

Every year, millions of brain MRI scans are acquired in hospitals, which is a figure
considerably larger than the size of any research dataset. Therefore, the ability to analyze …

Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across …

Humans vary substantially in their willingness to take risks. In a combined sample of over 1
million individuals, we conducted genome-wide association studies (GWAS) of general risk …

General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …