Current strategies in assessment of nanotoxicity: alternatives to in vivo animal testing
Millions of experimental animals are widely used in the assessment of toxicological or
biological effects of manufactured nanomaterials in medical technology. However, the …
biological effects of manufactured nanomaterials in medical technology. However, the …
Galleria mellonella as an infection model: an in-depth look at why it works and practical considerations for successful application
MF Pereira, CC Rossi, GC da Silva… - Pathogens and …, 2020 - academic.oup.com
The larva of the greater wax moth Galleria mellonella is an increasingly popular model for
assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents …
assessing the virulence of bacterial pathogens and the effectiveness of antimicrobial agents …
Selected strategies to fight pathogenic bacteria
A Plotniece, A Sobolev, CT Supuran… - Journal of enzyme …, 2023 - Taylor & Francis
Natural products and analogues are a source of antibacterial drug discovery. Considering
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
Biofilm models of polymicrobial infection
RA Gabrilska, KP Rumbaugh - Future microbiology, 2015 - Taylor & Francis
Interactions between microbes are complex and play an important role in the pathogenesis
of infections. These interactions can range from fierce competition for nutrients and niches to …
of infections. These interactions can range from fierce competition for nutrients and niches to …
What Can We Learn About Human Disease from the Nematode C. elegans?
J Apfeld, S Alper - Disease Gene Identification: Methods and Protocols, 2018 - Springer
Numerous approaches have been taken in the hunt for human disease genes. The
identification of such genes not only provides a great deal of information about the …
identification of such genes not only provides a great deal of information about the …
Forest and trees: exploring bacterial virulence with genome-wide association studies and machine learning
The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-
genome sequences to be generated at an unprecedented pace. This wealth of information …
genome sequences to be generated at an unprecedented pace. This wealth of information …
In vitro and ex vivo systems at the forefront of infection modeling and drug discovery
Bacterial infections and antibiotic resistant bacteria have become a growing problem over
the past decade. As a result, the Centers for Disease Control predict more deaths resulting …
the past decade. As a result, the Centers for Disease Control predict more deaths resulting …
Mouse models as resources for studying infectious diseases
Mouse models are important tools both for studying the pathogenesis of infectious diseases
and for the preclinical evaluation of vaccines and therapies against a wide variety of human …
and for the preclinical evaluation of vaccines and therapies against a wide variety of human …
3D human organoids: the next “viral” model for the molecular basis of infectious diseases
The COVID-19 pandemic has driven the scientific community to adopt an efficient and
reliable model that could keep up with the infectious disease arms race. Coinciding with the …
reliable model that could keep up with the infectious disease arms race. Coinciding with the …
Optimization and characterization of a Galleria mellonella larval infection model for virulence studies and the evaluation of therapeutics against Streptococcus …
F Cools, E Torfs, J Aizawa, B Vanhoutte… - Frontiers in …, 2019 - frontiersin.org
Streptococcus pneumoniae is the leading cause of bacterial pneumonia. Infection is linked
to high morbidity and mortality rates and antibiotic resistance within this pathogen is on the …
to high morbidity and mortality rates and antibiotic resistance within this pathogen is on the …