The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Regulatory themes and variations by the stress-signaling nucleotide alarmones (p) ppGpp in bacteria
Bacterial stress-signaling alarmones are important components of a protective network
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
ppGpp coordinates nucleotide and amino-acid synthesis in E. coli during starvation
Summary (p) ppGpp is a nucleotide messenger universally produced in bacteria following
nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several …
nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several …
Two P or not two P: understanding regulation by the bacterial second messengers (p) ppGpp
G Bange, DE Brodersen, A Liuzzi… - Annual Review of …, 2021 - annualreviews.org
Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …
The nucleotide pGpp acts as a third alarmone in Bacillus, with functions distinct from those of (p)ppGpp
J Yang, BW Anderson, A Turdiev, H Turdiev… - Nature …, 2020 - nature.com
The alarmone nucleotides guanosine tetraphosphate and pentaphosphate, commonly
referred to as (p) ppGpp, regulate bacterial responses to nutritional and other stresses …
referred to as (p) ppGpp, regulate bacterial responses to nutritional and other stresses …
The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus
BW Anderson, MA Schumacher, J Yang… - Nucleic Acids …, 2022 - academic.oup.com
The nucleotide messenger (p) ppGpp allows bacteria to adapt to fluctuating environments by
reprogramming the transcriptome. Despite its well-recognized role in gene regulation,(p) …
reprogramming the transcriptome. Despite its well-recognized role in gene regulation,(p) …
Possible roles for basal levels of (p) ppGpp: growth efficiency vs. surviving stress
L Fernández-Coll, M Cashel - Frontiers in Microbiology, 2020 - frontiersin.org
Two (p) ppGpp nucleotide analogs, sometimes abbreviated simply as ppGpp, are
widespread in bacteria and plants. Their name alarmone reflects a view of their function as …
widespread in bacteria and plants. Their name alarmone reflects a view of their function as …
Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase
D Fernández‐Justel, Í Marcos‐Alcalde… - Protein …, 2022 - Wiley Online Library
IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the rate‐limiting step in
the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain …
the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain …
ppGpp functions as an alarmone in metazoa
D Ito, H Kawamura, A Oikawa, Y Ihara… - Communications …, 2020 - nature.com
Abstract Guanosine 3′, 5′-bis (pyrophosphate)(ppGpp) functions as a second messenger
in bacteria to adjust their physiology in response to environmental changes. In recent years …
in bacteria to adjust their physiology in response to environmental changes. In recent years …
Molecular mechanism of regulation of the purine salvage enzyme XPRT by the alarmones pppGpp, ppGpp, and pGpp
The alarmones pppGpp and ppGpp mediate starvation response and maintain purine
homeostasis to protect bacteria. In the bacterial phyla Firmicutes and Bacteroidetes …
homeostasis to protect bacteria. In the bacterial phyla Firmicutes and Bacteroidetes …