Blood biomarkers in ischemic stroke: potential role and challenges in clinical practice and research
K Makris, A Haliassos, M Chondrogianni… - Critical reviews in …, 2018 - Taylor & Francis
Fast and accurate diagnosis of stroke is crucial for the immediate application of the right
therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke …
therapy to patients. However, rapid diagnosis is still a challenge since an ischemic stroke …
The dark side of the force–constraints and complications of cell therapies for stroke
Cell therapies are increasingly recognized as a promising option to augment the limited
therapeutic arsenal available to fight ischemic stroke. During the last two decades …
therapeutic arsenal available to fight ischemic stroke. During the last two decades …
Stem cell–based tissue replacement after stroke: factual necessity or notorious fiction?
Janowski et al Stem Cell–Based Stroke Therapies 2355 patient from this trial revealed
neurofilament-immunoreactive neurons at the graft location and the absence of neoplasms …
neurofilament-immunoreactive neurons at the graft location and the absence of neoplasms …
Evidence implicating blood-brain barrier impairment in the pathogenesis of acquired epilepsy following acute organophosphate intoxication
Organophosphate (OP) poisoning can trigger cholinergic crisis, a life-threatening toxidrome
that includes seizures and status epilepticus. These acute toxic responses are associated …
that includes seizures and status epilepticus. These acute toxic responses are associated …
Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery
Reactive nitrogen species (RNS) play important roles in mediating cerebral ischemia-
reperfusion injury. RNS activate multiple signaling pathways and participate in different …
reperfusion injury. RNS activate multiple signaling pathways and participate in different …
One-compound-multi-target: combination prospect of natural compounds with thrombolytic therapy in acute ischemic stroke
Tissue plasminogen activator (t-PA) is the only FDA-approved drug for acute ischemic stroke
treatment, but its clinical use is limited due to the narrow therapeutic time window and …
treatment, but its clinical use is limited due to the narrow therapeutic time window and …
The exact science of stroke thrombolysis and the quiet art of patient selection
JS Balami, G Hadley, BA Sutherland, H Karbalai… - Brain, 2013 - academic.oup.com
The science of metric-based patient stratification for intravenous thrombolysis, revolutionized
by the landmark National Institute of Neurological Disorders and Stroke trial, has …
by the landmark National Institute of Neurological Disorders and Stroke trial, has …
Recombinant tissue plasminogen activator induces neurological side effects independent on thrombolysis in mechanical animal models of focal cerebral infarction: a …
MX Dong, QC Hu, P Shen, JX Pan, YD Wei, YY Liu… - PloS one, 2016 - journals.plos.org
Background and Purpose Recombinant tissue plasminogen activator (rtPA) is the only
effective drug approved by US FDA to treat ischemic stroke, and it contains pleiotropic …
effective drug approved by US FDA to treat ischemic stroke, and it contains pleiotropic …
Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin
B Niego, N Lee, P Larsson, TM De Silva, AEL Au… - PLoS …, 2017 - journals.plos.org
Rho-kinase (ROCK) inhibition, broadly utilised in cardiovascular disease, may protect the
blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of …
blood-brain barrier (BBB) during thrombolysis from rt-PA-induced damage. While the use of …
Pharmacological therapy of acute ischaemic stroke: achievements and problems
Acute ischaemic stroke (AIS) is a leading cause of death and disability worldwide. Its
incidence and prevalence increase considerably with age and numbers will grow with an …
incidence and prevalence increase considerably with age and numbers will grow with an …