Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
Sound of silence: the properties and functions of repressive Lys methyltransferases
C Mozzetta, E Boyarchuk, J Pontis… - Nature Reviews Molecular …, 2015 - nature.com
The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates
chromatin organization and either activates or represses gene expression, depending on …
chromatin organization and either activates or represses gene expression, depending on …
The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing
C Mozzetta, J Pontis, L Fritsch, P Robin, M Portoso… - Molecular cell, 2014 - cell.com
G9a/GLP and Polycomb Repressive Complex 2 (PRC2) are two major epigenetic silencing
machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and …
machineries, which in particular methylate histone H3 on lysines 9 and 27 (H3K9 and …
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells
Histone methyltransferases and demethylases reversibly modulate histone lysine
methylation, which is considered a key epigenetic mark associated with gene regulation …
methylation, which is considered a key epigenetic mark associated with gene regulation …
Targeting histone lysine methylation in cancer
J McGrath, P Trojer - Pharmacology & therapeutics, 2015 - Elsevier
Within the vast landscape of histone modifications lysine methylation has gained increasing
attention because of its profound regulatory potential. The methylation of lysine residues on …
attention because of its profound regulatory potential. The methylation of lysine residues on …
G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition
Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …
Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised β-adrenergic signaling in an iPSC model of dilated cardiomyopathy
Summary β-adrenergic signaling pathways mediate key aspects of cardiac function. Its
dysregulation is associated with a range of cardiac diseases, including dilated …
dysregulation is associated with a range of cardiac diseases, including dilated …
Tug of war: adding and removing histone lysine methylation in Arabidopsis
Highlights•Genome wide distribution and function of H3K4, K27, K36me in plant and
animal.•Summary of histone lysine methylation writer, eraser and reader in plant and …
animal.•Summary of histone lysine methylation writer, eraser and reader in plant and …
G9a, a multipotent regulator of gene expression
SR Shankar, AG Bahirvani, VK Rao, N Bharathy… - Epigenetics, 2013 - Taylor & Francis
Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is
mostly associated with transcriptional repression. Recent studies, however, have highlighted …
mostly associated with transcriptional repression. Recent studies, however, have highlighted …
The histone H3K4 demethylase JMJ16 represses leaf senescence in Arabidopsis
Leaf senescence is governed by a complex regulatory network involving the dynamic
reprogramming of gene expression. Age-dependent induction of senescence-associated …
reprogramming of gene expression. Age-dependent induction of senescence-associated …