Novel approaches to target fibroblast mechanotransduction in fibroproliferative diseases
The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …
Biocatalysis by transglutaminases: a review of biotechnological applications
MP Savoca, E Tonoli, AG Atobatele, EAM Verderio - Micromachines, 2018 - mdpi.com
The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent
isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but …
isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but …
[HTML][HTML] Heparin–protein interactions: from affinity and kinetics to biological roles. Application to an interaction network regulating angiogenesis
F Peysselon, S Ricard-Blum - Matrix biology, 2014 - Elsevier
Numerous extracellular proteins, growth factors, chemokines, cytokines, enzymes,
lipoproteins, involved in a variety of biological processes, interact with heparin and/or …
lipoproteins, involved in a variety of biological processes, interact with heparin and/or …
[HTML][HTML] Transglutaminase 2 has higher affinity for relaxed than for stretched fibronectin fibers
Abstract Transglutaminase 2 (TG2) plays a vital role in stabilizing extracellular matrix (ECM)
proteins through enzymatic crosslinking during tissue growth, repair, and inflammation. TG2 …
proteins through enzymatic crosslinking during tissue growth, repair, and inflammation. TG2 …
Enhanced Penetration and Retention of CuS‐Based Nanosystem Through NIR Light and In Situ Enzyme Response for Improved Tumor Therapy
F Gao, L Zhu, L Jiang, J Zhang, S Ji… - Advanced Functional …, 2024 - Wiley Online Library
The efficient way to increase the therapeutic efficacy of nanomedicines is by encouraging
the penetration and enhancing the retention of nanoparticles at the tumor site. However, it is …
the penetration and enhancing the retention of nanoparticles at the tumor site. However, it is …
[PDF][PDF] TGM2 and implications for human disease: role of alternative splicing
TS Lai, CS Greenberg - Front. Biosci, 2013 - researchgate.net
Introduction 3. Biochemistry of TGM2 3.1. Transamidation Reaction (TGase) 3.2. Regulation
of TGase 3.3. G protein and Kinase. 4. Structure and Function of TGM2 4.1. TGase active site …
of TGase 3.3. G protein and Kinase. 4. Structure and Function of TGM2 4.1. TGase active site …
Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis
A Scarpellini, L Huang, I Burhan… - Journal of the …, 2014 - journals.lww.com
Abstract Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a
pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan …
pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan …
Implications of enigmatic transglutaminase 2 (TG2) in cardiac diseases and therapeutic developments
GFA Doa'a, CC Tranchant, A Al-Dwairi… - Biochemical …, 2022 - Elsevier
Cardiac diseases are the leading cause of mortality and morbidity worldwide. Mounting
evidence suggests that transglutaminases (TGs), tissue TG (TG2) in particular, are involved …
evidence suggests that transglutaminases (TGs), tissue TG (TG2) in particular, are involved …
Physiological, pathological, and structural implications of non-enzymatic protein–protein interactions of the multifunctional human transglutaminase 2
Abstract Transglutaminase 2 (TG2) is a ubiquitously expressed member of an enzyme family
catalyzing Ca 2+-dependent transamidation of proteins. It is a multifunctional protein having …
catalyzing Ca 2+-dependent transamidation of proteins. It is a multifunctional protein having …
Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
XY Qin, Y Furutani, K Yonezawa, N Shimizu… - Cell Death & …, 2023 - nature.com
Abstract Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses
tumorigenesis, depending on intracellular location and conformational structure. Acyclic …
tumorigenesis, depending on intracellular location and conformational structure. Acyclic …