Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

The continuous demand of medicinally important scaffolds has prompted the synthetic
chemists to identify simple and efficient routes for their synthesis. 1H-1, 2, 3-triazole …

Infectious diseases resulting from various strains of pathogenic bacteria are among the
leading causes of death and morbidity worldwide. The currently-available antibacterial …

Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Background: The indole framework is considered as one of the privileged structures in the
area of medicinal chemistry and drug discovery because compounds containing this …

Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …

Indole-containing small molecules have been reported to have diverse pharmacological
activities. The aromatic heterocyclic scaffold, which resembles various protein structures …

Ultrasound-assisted, mild and highly efficient route for the one-pot multicomponent reaction
of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid has been …

The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …

The present work describes design of a small library of new 1, 2, 3-triazole-appended bis-
pyrazoles by using a molecular hybridization approach, and the synthesized hybrids were …