Arginine (L-arginine), is an amino acid involved in a number of biological processes,
including the biosynthesis of proteins, host immune response, urea cycle, and nitric oxide …

Vascular aging, a determinant factor for cardiovascular disease and health status in the
elderly, is now viewed as a modifiable risk factor. Impaired endothelial vasodilation is a early …

Diminished bioavailability of nitric oxide (NO), the gaseous signaling molecule involved in
the regulation of numerous vital biological functions, contributes to the development and …

The endothelium is composed of a monolayer of endothelial cells, lining the interior surface
of blood and lymphatic vessels. Endothelial cells display important homeostatic functions …

Advancing age is the major risk factor for the development of CVD (cardiovascular
diseases). This is attributable, in part, to the development of vascular endothelial …

Aging is associated with impaired vascular endothelial function, as indicated in part by
reduced endothelium-dependent dilation (EDD). Decreased EDD with aging is thought to be …

One of the major conceptual advances in our understanding of the pathogenesis of age-
associated cardiovascular diseases has been the insight that age-related oxidative stress …

Aging is an important risk factor for the development of many cardiovascular diseases as
atherosclerosis and hypertension with a common underlying circumstance: the progressive …

Reactive oxygen species (ROS) including superoxide (O2.−) and hydrogen peroxide (H2O2)
are produced endogenously in response to cytokines, growth factors; G-protein coupled …

AIMS: Poor blood flow and hypoxia/ischemia contribute to many disease states and may
also be a factor in the decline of physical and cognitive function in aging. Nitrite has been …