Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for
significant mortality and morbidity worldwide. The genus comprises more than seventy …

West Nile virus (WNV) is a widely spread human pathogenic arthropod-borne virus. It can
lead to severe, sometimes fatal, neurological disease. Over the last two decades, several …

PLX5622 is a CSF-1R inhibitor and microglia-depleting reagent, widely used to investigate
the biology of this central nervous system (CNS)-resident myeloid population, but the …

The increasing geographical spread and disease incidence of arboviral infections are
among the greatest public health concerns in the Americas. The region has observed an …

Flaviviruses such as dengue, yellow fever, Zika, West Nile, and Japanese encephalitis virus
present substantial global health burdens. New vaccines are being sought to address safety …

Mosquito borne viral diseases are an emerging threat as evident from the recent outbreak of
Zika virus (ZIKV) as well as repeated outbreaks of Chikungunya (CHIKV), Yellow fever (YFV) …

The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently
neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1–DENV4). Here …

Infections with dengue virus (DENV) and Zika virus (ZIKV) can induce cross-reactive
antibody responses. Two immunodominant epitopes—one to precursor membrane protein …

Flaviviruses are still a hidden threat to global human safety, as we are reminded by recent
reports of dengue virus infections in Singapore and African-lineage-like Zika virus infections …

The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …