The vascular endothelial growth factor (VEGF), a homodimeric vasoactive glycoprotein, is
the key mediator of angiogenesis. Angiogenesis, the formation of new blood vessels, is …

Aptamers are single-stranded DNA or RNA sequences that bind target molecules with high
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …

Fragment-based drug design has introduced a bottom-up process for drug development,
with improved sampling of chemical space and increased effectiveness in early drug …

The binding between two biomolecules is one of the most critical factors controlling many
bioprocesses. Therefore, it is of great interest to derive a reliable method to calculate the free …

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets
for treatment for thrombotic disorders and thereby their inhibitors can serve as effective …

Radix Salviae miltiorrhizae, danshen root (danshen), is one of the widely used Chinese
herbal medicines in clinics, containing rich phenolic compounds. Salvianolic acid is the …

Myocardial infarction (MI) remains the leading cause of cardiovascular death worldwide.
Studies have shown that soluble fms-like tyrosine kinase-1 (sFlt-1) has a harmful effect on …

As a pathological coagulation process, thrombus can lead to many serious diseases,
including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome …

CB2R are fascinating targets for neuropathic pain and mood disorders because of their
improved biological characteristics. Experimental data on 1296 cannabinoid-2 receptor …

Green chemistry implementation has led to promising results in waste reduction in the
pharmaceutical industry. However, the early sustainable development of pharmaceutically …