Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …

Polymer-based nanoparticles of tailored size, morphology, and surface properties have
attracted increasing attention as carriers for drugs, biomolecules, and genes. By protecting …

Background Inner ear diagnostics is limited by the inability to atraumatically obtain samples
of inner ear fluid. The round window membrane (RWM) is an attractive portal for accessing …

Over the last several decades, both the academic and therapeutic fields have seen
significant progress in the delivery of drugs to the inner ear due to recent delivery methods …

Meniere's disease (MD) is a severe inner ear condition known by debilitating symptoms,
including spontaneous vertigo, fluctuating and progressive hearing loss, tinnitus, and aural …

Despite significant research progress in substantiating the therapeutic merits of
nanomedicines and the emergence of sophisticated nanotechnologies, the translation of this …

Background: Sensorineural hearing loss has been associated with oxidative stress.
However, an antioxidant that passes effectively through the ear remains elusive. Method …

Drug delivery into the inner ear is a significant challenge due to its inaccessibility as a fluid-
filled cavity within the temporal bone of the skull. The round window membrane (RWM) is the …

Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in
particular the sensitive hair cells, can impact individuals for the rest of their lives. There are …

Despite significant advances in the development of therapeutics for hearing loss, drug
delivery to the middle and inner ear remains a challenge. As conventional oral or …