This review provides an extensive summary of the effects of carbohydrate fluorination with
regard to changes in physical, chemical and biological properties with respect to regular …

Sialic acid is an important component of cell surface glycans, which are responsible for
many vital body functions and should therefore be thoroughly studied to understand their …

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable.
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …

The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein
thrombosis and acute pulmonary embolism since 2002 and is considered to be better than …

Carbohydrates make up one of the four major classes of biomolecules, often conjugated
with proteins as glycoproteins or with lipids as glycolipids, and participate in many important …

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …

A comprehensive structure–activity relationship study on antibody Fc-glycosylation has been
performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2, 6 …

The gut pathogen Clostridium bolteae has been associated with the onset of autism
spectrum disorder (ASD). To create vaccines against C. bolteae, it is important to identify …

Highlights•Carbohydrate-active enzymes (CAZymes) are invaluable tools for the synthesis of
glycoconjugates.•Manipulation of the glycosidic linkage (synthesis and hydrolysis) are …

The importance of post-translational glycosylation in protein structure and function has
gained significant clinical relevance recently. The latest developments in glycobiology …