Fluorinated carbohydrates as chemical probes for molecular recognition studies. Current status and perspectives
B Linclau, A Ardá, NC Reichardt, M Sollogoub… - Chemical Society …, 2020 - pubs.rsc.org
This review provides an extensive summary of the effects of carbohydrate fluorination with
regard to changes in physical, chemical and biological properties with respect to regular …
regard to changes in physical, chemical and biological properties with respect to regular …
Advanced chemical methods for stereoselective sialylation and their applications in sialoglycan syntheses
AM Vibhute, N Komura, HN Tanaka… - The Chemical …, 2021 - Wiley Online Library
Sialic acid is an important component of cell surface glycans, which are responsible for
many vital body functions and should therefore be thoroughly studied to understand their …
many vital body functions and should therefore be thoroughly studied to understand their …
Automated quantification of hydroxyl reactivities: Prediction of glycosylation reactions
The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable.
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …
We have developed a database of acceptor nucleophilic constants (Aka) to quantify the …
Programmable one-pot synthesis of heparin pentasaccharide fondaparinux
The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein
thrombosis and acute pulmonary embolism since 2002 and is considered to be better than …
thrombosis and acute pulmonary embolism since 2002 and is considered to be better than …
Programmable one-pot synthesis of oligosaccharides
Carbohydrates make up one of the four major classes of biomolecules, often conjugated
with proteins as glycoproteins or with lipids as glycolipids, and participate in many important …
with proteins as glycoproteins or with lipids as glycolipids, and participate in many important …
Structural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation
LD Movsisyan, MS Macauley - Organic & biomolecular chemistry, 2020 - pubs.rsc.org
Sialic acid-binding immunoglobulin-like lectins (Siglecs) are transmembrane proteins of the
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …
immunoglobulin (Ig) superfamily predominantly expressed on the cells of our immune …
Study on antibody Fc-glycosylation for optimal effector functions
VS Shivatare, PK Chuang, TH Tseng… - Chemical …, 2023 - pubs.rsc.org
A comprehensive structure–activity relationship study on antibody Fc-glycosylation has been
performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2, 6 …
performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2, 6 …
Chemical Synthesis Elucidates the Key Antigenic Epitope of the Autism‐Related Bacterium Clostridium bolteae Capsular Octadecasaccharide
J Cai, J Hu, C Qin, L Li, D Shen, G Tian… - Angewandte Chemie …, 2020 - Wiley Online Library
The gut pathogen Clostridium bolteae has been associated with the onset of autism
spectrum disorder (ASD). To create vaccines against C. bolteae, it is important to identify …
spectrum disorder (ASD). To create vaccines against C. bolteae, it is important to identify …
Enzyme promiscuity of carbohydrate active enzymes and their applications in biocatalysis
E Pallister, CJ Gray, SL Flitsch - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Carbohydrate-active enzymes (CAZymes) are invaluable tools for the synthesis of
glycoconjugates.•Manipulation of the glycosidic linkage (synthesis and hydrolysis) are …
glycoconjugates.•Manipulation of the glycosidic linkage (synthesis and hydrolysis) are …
Synthetic carbohydrate chemistry and translational medicine
SS Shivatare, CH Wong - The Journal of organic chemistry, 2020 - ACS Publications
The importance of post-translational glycosylation in protein structure and function has
gained significant clinical relevance recently. The latest developments in glycobiology …
gained significant clinical relevance recently. The latest developments in glycobiology …