Anderson–Fabry disease (AFD) is a rare disease with an incidenceof approximately 1:
117,000 male births. Lysosomal accumulation of globotriaosylceramide (Gb3) is the element …

Podocytopathies are kidney diseases that are driven by podocyte injury with proteinuria and
proteinuria-related symptoms as the main clinical presentations. Albeit podocytopathies are …

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular
processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the …

Necroptosis is a type of programmed cell death that is morphologically similar to necrosis.
This type of cell death is involved in various pathophysiological disorders, including …

Fabry disease stems from a deficiency of alpha-galactosidase and results in the
accumulation of globotriaosylceramide (Gb3). However, the production of its deacylated …

Podocyte loss is well known to play a critical role in the early progression of diabetic
nephropathy. A growing number of studies are paying attention to necroptosis, a …

Lysosomal storage diseases are a group of rare and ultra-rare genetic disorders caused by
defects in specific genes that result in the accumulation of toxic substances in the lysosome …

Podocyte health is vital for maintaining proper glomerular filtration in the kidney.
Interdigitating foot processes from podocytes form slit diaphragms which regulate the …

Background Diabetic nephropathy (DN) is characterized by albuminuria and accumulation
of extracellular matrix (ECM) in kidney. Transforming growth factor-β (TGF-β) plays a central …

The pathophysiology of Fabry nephropathy (FN) is induced by galactosidase A deficiency
with a chronic exposure of glycolipids to every lineage of renal cells. Tissue damage is …