Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

The ATP-binding cassette (ABC) transporter superfamily is found in all domains of life,
facilitating critical biological processes through the translocation of a wide variety of …

SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and
TolC outer membrane exit duct to expel antibiotics and export virulence factors from Gram …

ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a
wide variety of substrates across cellular membranes and are conserved from bacteria to …

Mycobacterium tuberculosis is known to synthesize α-, methoxy-, and keto-mycolic acids.
We propose a detailed pathway to the biosynthesis of all mycolic acids in M. tuberculosis …

▪ Abstract ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and
efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these …

Membrane proteins responsible for the active efflux of structurally and functionally unrelated
drugs were first characterized in higher eukaryotes. To date, a vast number of transporters …

It was first discovered in 1992 that P-glycoprotein (Pgp, ABCB1), an ATP binding cassette
(ABC) transporter, can transport phospholipids such as phosphatidylcholine,− ethanolamine …

The rapid emergence of multidrug-resistant (MDR) bacteria indisputably constitutes a major
global health problem. Pathogenic Escherichia coli are listed among the most critical group …