Transcriptional regulation in archaea: from individual genes to global regulatory networks

M Martinez-Pastor, PD Tonner… - Annual review of …, 2017 - annualreviews.org
Archaea are major contributors to biogeochemical cycles, possess unique metabolic
capabilities, and resist extreme stress. To regulate the expression of genes encoding these …

Regulatory network features in Listeria monocytogenes—changing the way we talk

V Guariglia-Oropeza, RH Orsi, H Yu, KJ Boor… - Frontiers in cellular …, 2014 - frontiersin.org
Our understanding of how pathogens shape their gene expression profiles in response to
environmental changes is ever growing. Advances in Bioinformatics have made it possible …

Systematic discovery of archaeal transcription factor functions in regulatory networks through quantitative phenotyping analysis

CL Darnell, PD Tonner, JG Gulli, SC Schmidler… - …, 2017 - Am Soc Microbiol
Gene regulatory networks (GRNs) are critical for dynamic transcriptional responses to
environmental stress. However, the mechanisms by which GRN regulation adjusts …

Genomics-based insights into the evolution of secondary metabolite biosynthesis in actinomycete bacteria

SB Zotchev - … biology: genome evolution, speciation, coevolution and …, 2014 - Springer
Actinomycete bacteria are known for their ability to produce chemically diverse secondary
metabolites with various biological activities, some of which are being used in human …

Proteins needed to activate a transcriptional response to the reactive oxygen species singlet oxygen

TW Nam, EC Ziegelhoffer, RAS Lemke, TJ Donohue - MBio, 2013 - Am Soc Microbiol
ABSTRACT Singlet oxygen (1O2) is a reactive oxygen species generated by energy transfer
from one or more excited donors to molecular oxygen. Many biomolecules are prone to …

Shedding light on a Group IV (ECF11) alternative σ factor

TJ Donohue - Molecular Microbiology, 2019 - Wiley Online Library
This year marks the 50th anniversary of the discovery of σ70 as a protein factor that was
needed for bacterial RNA polymerase to accurately transcribe a promoter in vitro. It was 25 …

Bayesian modeling of microbial physiology

PD Tonner - 2017 - search.proquest.com
Microbial population growth measurements are widespread in the study of microorganisms,
providing insight into areas including genetics, physiology, and engineering. The most …