Dichloroacetate (DCA) has several therapeutic applications based on its pharmacological
property of inhibiting pyruvate dehydrogenase kinase. DCA has been used to treat inherited …

Dichloroacetate (DCA) is a naturally occurring xenobiotic that has been used as an
investigational drug for over 50 years. Originally found to lower blood glucose levels and …

Herein I summarize the physiological chemistry and pharmacology of the bifunctional
enzyme glutathione transferase zeta 1 (GSTZ1)/maleylacetoacetate isomerase (MAAI) …

The investigational drug dichloroacetate (DCA) is a metabolic regulator that has been
successfully used to treat acquired and congenital metabolic diseases and, recently, solid …

We recently reported that, in a concentration-dependent manner, chloride protects hepatic
glutathione transferase zeta 1 from inactivation by dichloroacetate, an investigational drug …

Dichloroacetate (DCA), commonly used to treat metabolic disorders, is under investigation
as an anti-cancer therapy due to its ability to reverse the Warburg effect and induce …

Background Prenatal disinfection by-products (DBPs) exposure is linked with adverse birth
outcomes. Genetic susceptibility to DBP metabolism may modify the exposure-outcome …

Dichloroacetate (DCA) is an investigational drug used to treat lactic acidosis and malignant
tumours. It works by inhibiting pyruvate dehydrogenase kinase and increasing the rate of …

Trihalomethanes (THMs) have been reported to be associated with altered semen quality,
and this association may be modified by inherited differences in cytochrome P450 (CYP2E1) …

The effects of disinfection byproducts (DBPs) on adverse birth outcomes remain unsettled.
Maternal genetic variants in relation to DBP metabolism may modify this effect. Pregnant …