[HTML][HTML] Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1, 4, 5-trisubstituted 1, 2, 3-triazoles …

ZY Ibrahim, A Uzairu, G Shallangwa, S Abechi - Scientific African, 2020 - Elsevier
Malaria is a killer disease caused by Plasmodium falciparum and is responsible for over a
million death annually. Chloroquine, quinine, pyrimethamine, proguanil, artemisinin …

DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition

M Mirza-Aghazadeh-Attari, MJ Recio, SG Darband… - DNA repair, 2021 - Elsevier
Breast cancer is the most common and significant cancers in females regarding the loss of
life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA …

Chemical and toxicological studies on black crust formed over historical monuments as a probable health hazard

N Islam, K Roy, P Barman, S Rabha, HK Bora… - Journal of Hazardous …, 2024 - Elsevier
Studies to date have mostly investigated environmental factors responsible for deterioration
of historical monuments. Black crusts formed on historical monuments are considered as …

Recent progress on apoptotic activity of triazoles

P Çıkla-Süzgün, ŞG Küçükgüzel - Current drug targets, 2021 - ingentaconnect.com
Apoptosis is often called programmed cell death and is defined as a self-directed cell
destruction process. It is different from necrosis due to the activation of caspases during this …

Induction of autophagy and autophagy‐dependent apoptosis in diffuse large B‐cell lymphoma by a new antimalarial artemisinin derivative, SM 1044

C Cheng, T Wang, Z Song, L Peng, M Gao… - Cancer …, 2018 - Wiley Online Library
Diffuse large B‐cell lymphoma (DLBCL) is the most common form of non‐Hodgkin's
lymphoma. R‐CHOP is currently the standard therapy for DLBCL, but the prognosis of …

Synthesis of novel 1, 2, 3-triazole based artemisinin derivatives and their antiproliferative activity

DS Kapkoti, S Singh, S Luqman… - New Journal of Chemistry, 2018 - pubs.rsc.org
Two series of novel 1, 2, 3-triazole based artemisinin derivatives were designed,
synthesized via a copper (I)-catalyzed azide alkyne cycloaddition (CuAAC) reaction and …

Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and …

A Arun, OPS Patel, D Saini, PP Yadav… - Biomedicine & …, 2017 - Elsevier
In recent years, many alkaloids of plant origin have attracted great attention due to their
diverse range of biological properties including anti-hyperglycemic, anti-oxidant, anti …

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

R Li, P Zhou, Y Guo, JS Lee, B Zhou - Food and Chemical Toxicology, 2017 - Elsevier
Abstract Tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP), an extensively used
organophosphorus flame retardant, is frequently detected in the environment and biota …

Detection of fluoride ions using carbon quantum dots derived from coal washery rejects via an on–off–on fluorescence mechanism: a smartphone-based image …

A Boruah, A Rajbonshi, K Roy, BK Saikia - New Journal of Chemistry, 2024 - pubs.rsc.org
Given the high toxicity and easy availability of fluoride ions in surface as well as ground
water, an on–off–on fluorescence process-based fluoride ion sensor is developed by using …

Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell …

D Mandalapu, KS Saini, S Gupta, V Sharma… - Bioorganic & Medicinal …, 2016 - Elsevier
The anti-cancer property of curcumin, an active component of turmeric, is limited due to its
poor solubility, stability and bioavailability. To enhance its efficacy, we designed a novel …