Graves' disease (GD) is characterized by thyrotoxicosis, caused by the presence of
circulating thyroid stimulating antibodies (TSAb), that are determinant also in the …

Systemic sclerosis (SSc) is a chronic immune disorder of unknown origin, dominated by
excessive fibrosis responsible for cutaneous and pulmonary fibrosis, and by vascular …

Background Systemic sclerosis-associated interstitial lung disease (ILD) carries a high
mortality risk; expert guidance is required to aid early recognition and treatment. We aimed …

Objectives SSc is characterized by fibrotic changes in the skin and lung, and the mainstay of
treatment has been CYC. B cell involvement suggests that rituximab (RTX) may also be of …

Objective To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical
practice. Methods We performed a prospective study including patients with SSc from the …

Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients
with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in …

Systemic sclerosis (SSc) is a generalized disease of the connective tissue, arterioles, and
microvessels, characterized by the appearance of fibrosis and vascular obliteration. There …

Rheumatoid arthritis (RA) is often characterized by bone loss and fragility fractures and is a
frequent comorbidity. Compared with a matched population, RA patients with fractures have …

Systemic sclerosis (SSc) is a complex rheumatologic autoimmune disease in which
inflammation, fibrosis, and vasculopathy share several pathogenic pathways that lead to …

The steadily increasing knowledge regarding pathogenetic mechanisms in autoimmune
rheumatic diseases has paved the way to different therapeutic approaches. In particular, the …