Autoimmune myopathies (myositides) are strongly associated with malignancy. The link
between myositis and cancer, originally noticed by Bohan and Peter in their classification in …

The microrchidia (MORC) family of proteins is a highly conserved nuclear protein
superfamily, whose members contain common domain structures (GHKL-ATPase, CW-type …

Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes.
Although specific ERV loci feature regulatory roles for host gene expression, most ERV …

Rationale: SUMOylation regulates a plethora of biological processes, and its inhibitors are
currently under investigation in clinical trials as anticancer agents. Thus, identifying new …

Background Breast cancer is the leading cause of cancer‐related deaths in women,
demanding new treatment options. With the advent of immune checkpoint blockade …

Idiopathic inflammatory myopathies (IIMs) comprise a heterogeneous group of rare immune‐
mediated disorders that primarily affect muscles but also lead to dysfunction in other organs …

Background Baicalin is a natural compound from the roots of Scutellaria lateriflora Georgi,
which plays anti-cancer role in multiple cancers. However, the exact role and potential …

Microrchidia (MORC) proteins comprise a family of proteins that have been identified in
prokaryotes and eukaryotes. They are defined by two hallmark domains: a GHKL-type …

Abstract Background Microrchidia proteins (MORCs) are involved in epigenetic gene
silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several …

The identification of anti-NXP2 antibodies is considered a serological marker of
dermatomyositis (DM), with calcinosis, severe myositis and, in some reports, with cancer …