Multidrug-resistant (MDR) tuberculosis (TB), resistant to isoniazid and rifampicin, continues
to be one of the most important threats to controlling the TB epidemic. Over the last few …

Introduction: Linezolid is an oxazolidinone with potent activity against M tuberculosis, and
improves culture conversion and cure rates when added to treatment regimens for drug …

Objectives Prolonged treatment with linezolid may cause toxicity. The purpose of this study
was to define pharmacodynamic thresholds for improving safety outcomes of linezolid …

La creciente tasa de resistencia de Staphylococcus aureus a meticilina (SARM) observada
en la década de los años 90, generó importantes lineas de estudio de nuevos antibióticos …

Introduction: Oxazolidinones are synthetic antimicrobials with strong bacteriostatic activity
against Gram-positive organisms. Recently, tedizolid phosphate was approved for clinical …

The use of linezolid for the treatment of multidrug-resistant tuberculosis is limited by dose-
and time-dependent toxicity. Recently, we reported a case of pharmacokinetic drug–drug …

Linezolid is a promising antimicrobial agent for the treatment of multidrug-resistant
tuberculosis (MDR-TB), but its use is limited by toxicity. Therapeutic drug monitoring (TDM) …

Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions.
These drug interactions are a major concern in clinical practice as they may have an effect …

Linezolid is used increasingly for the treatment of multi-drug-resistant (MDR) and extensively-
drug-resistant (XDR) tuberculosis (TB). However, linezolid can cause severe adverse …

Background The objectives of the present prospective observational study conducted in
patients receiving conventional dosage of linezolid was to define the pharmacodynamic …