Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a major public health
concern, but the mechanisms underlying its viral particle formation are not well understood …

A current challenge is the emergence of SARS-CoV-2 variants, such as BQ. 1.1 and XBB.
1.5, that can evade immune defenses, thereby limiting antibody drug effectiveness …

Evolved SARS-CoV-2 variants of concern (VOCs) spread through human populations in
succession. Major virus variations are in the entry-facilitating viral spike (S) proteins; …

During a coronavirus infection, the spike protein undergoes sequential structural transitions
triggered by its receptor and the host protease at the interface between the virus and cell …

Here we present a protocol to measure coronavirus-mediated membrane fusion, an
essential event in coronavirus cell entry. The approach uses nanoluciferase (Nluc)“HiBiT” …

The fusion peptide of SARS-CoV-2 spike is essential for infection. How this charged and
hydrophobic domain occupies and affects membranes needs clarification. Its depth in …

Currently circulating SARS-CoV-2 variants have gained complete or significant resistance to
all SARS-CoV-2-neutralizing antibodies that have been used in the clinic. Such antibodies …

Cryoelectron tomography (cryo-ET) has become an indispensable technology for visualizing
in situ biological ultrastructures, where the tilt series alignment is the key step to obtain a …

As obligate pathogens, viruses have developed diverse mechanisms to deliver their
genome across host cell membranes to sites of virus replication. While enveloped viruses …

Visualizations play a critical role in discovering, understanding, interpreting, synthesizing,
and communicating scientific knowledge. Effective scientific visualization requires careful …