Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Parkinson's disease (PD) is the second most common neurodegenerative disorder mostly
affecting the aging population over sixty. Cardinal symptoms including, tremors, muscle …

In two decades, the solid state and polymer nanopores became attractive method for the
protein sensing with high specificity and sensitivity. They also allow the characterization of …

The last 15 years saw a dramatic increase in the number of published papers exposing
research related to the concept of protein disorder and a concomitant increase in the …

Abstract α-Synuclein (α-Syn) is an abundant cytosolic protein involved in the release of
neurotransmitters in presynaptic terminal and its aberrant aggregation is found to be …

Aggregates of misfolded proteins are associated with several devastating
neurodegenerative diseases. These socalled amyloids are therefore explored as …

For the past 2 decades, emerging single-nanopore technologies have opened the route to
multiple sensing applications. Besides DNA sensing, the identification of proteins and …

Nanopores employ a confined space for electrochemical sensing of highthroughput
individual biomolecules in solution. Tremendous research efforts over the last two decades …

The effectiveness of noninvasive treatment for neurological disease is generally limited by
the poor entry of therapeutic agents into the central nervous system (CNS). Most CNS drugs …

Botulinum neurotoxins (BoNTs) are the most lethal toxin known to human. Biodefense
requires early and rapid detection of BoNTs. Traditionally, BoNTs can be detected by …