Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

Cytosolic innate immune sensors are critical for host defense and form complexes, such as
inflammasomes and PANoptosomes, that induce inflammatory cell death. The sensor …

Single-cell genomics technology has transformed our understanding of complex cellular
systems. However, excessive cost and a lack of strategies for the purification of newly …

Single-cell molecular tools have been developed at an incredible pace over the last five
years as sequencing costs continue to drop and numerous molecular assays have been …

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers
of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic …

Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception.
Understanding the site-and stage-specific variation in hematopoiesis is important if we are to …

The past five decades have seen significant progress in our understanding of human
hematopoiesis. This has in part been due to the unprecedented development of advanced …

Although cytokine-mediated expansion of human hematopoietic stem cells (HSCs) can
result in high yields of hematopoietic progenitor cells, this generally occurs at the expense of …

Telocytes (TCs) are a newly discovered type of mesenchymal cell that are closely related to
the tissue's internal environment. The study aimed to investigate the morphological …

The consequences of sickle cell disease (SCD) include ongoing hematopoietic stress,
hemolysis, vascular damage, and effect of chronic therapies, such as blood transfusions and …