The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

In an aging society, research involving neurodegenerative disorders is of paramount
importance. Over the past few years, research on Alzheimer's and Parkinson's diseases has …

Alzheimer's disease (AD) is a progressive disease and one of the most common forms of
neurodegenerative disorders. Emerging evidence is supporting the use of various strategies …

Drosophila has been the key model system for studies on planar cell polarity (PCP). The rich
morphology of the insect exoskeleton contains many structures that display PCP. Among …

How stem cells produce the huge diversity of neurons that form the visual system, and how
these cells are assembled in neural circuits are a critical question in developmental …

Morphogenesis is one of the most remarkable examples of biological pattern formation.
Despite substantial progress in the field, we still do not understand the organizational …

The molecular processes that drive gene transcription are inherently noisy. This noise often
manifests in the form of transcriptional bursts, producing fluctuations in gene activity over …

Tissue organization is often characterized by specific patterns of cell morphology. How such
patterns emerge in developing tissues is a fundamental open question. Here, we investigate …

About two-thirds of the vital genes in the Drosophila genome are involved in eye
development, making the fly eye an excellent genetic system to study cellular function and …

The centrosome is the best-understood microtubule-organizing center (MTOC) and is
essential in particular cell types and at specific stages during Drosophila development. The …