The neurochemical profile quantified by in vivo 1H NMR spectroscopy

JMN Duarte, H Lei, V Mlynárik, R Gruetter - Neuroimage, 2012 - Elsevier
Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

Imaging devices for use in small animals

W Koba, K Kim, ML Lipton, L Jelicks, B Das… - Seminars in nuclear …, 2011 - Elsevier
Imaging devices for small animals have emerged in the past 10 years as extraordinarily
useful tools in translational research and drug development. The Food and Drug …

Heteronuclear micro-Helmholtz coil facilitates µm-range spatial and sub-Hz spectral resolution NMR of nL-volume samples on customisable microfluidic chips

N Spengler, J Hoefflin, A Moazenzadeh, D Mager… - PloS one, 2016 - journals.plos.org
We present a completely revised generation of a modular micro-NMR detector, featuring an
active sample volume of∼ 100 nL, and an improvement of 87% in probe efficiency. The …

Targeting protein kinase CK2: evaluating CX-4945 potential for GL261 glioblastoma therapy in immunocompetent mice

L Ferrer-Font, L Villamañan, N Arias-Ramos… - Pharmaceuticals, 2017 - mdpi.com
Glioblastoma (GBM) causes poor survival in patients even with aggressive treatment.
Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment but …

Anti-pd-1 immunotherapy in preclinical gl261 glioblastoma: Influence of therapeutic parameters and non-invasive response biomarker assessment with mrsi-based …

S Wu, P Calero-Pérez, C Arús, AP Candiota - International journal of …, 2020 - mdpi.com
Glioblastomas (GBs) are malignant brain tumours with poor prognosis even after aggressive
therapy. Programmed cell death-1 (PD-1) immune checkpoint blockade is a promising …

Tracking Therapy Response in Glioblastoma Using 1D Convolutional Neural Networks

S Ortega-Martorell, I Olier, O Hernandez… - Cancers, 2023 - mdpi.com
Simple Summary Glioblastoma (GB) is a malignant brain tumour with no cure, even after the
best treatment. The evaluation of a therapy response is usually based on magnetic …

Anti‐tumour immune response in GL261 glioblastoma generated by Temozolomide Immune‐Enhancing Metronomic Schedule monitored with MRSI‐based …

S Wu, P Calero‐Pérez, L Villamañan… - NMR in …, 2020 - Wiley Online Library
Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy.
Improvements in both therapeutic and follow‐up strategies are urgently needed. In previous …

Metronomic treatment in immunocompetent preclinical GL261 glioblastoma: effects of cyclophosphamide and temozolomide

L Ferrer‐Font, N Arias‐Ramos… - NMR in …, 2017 - Wiley Online Library
Glioblastoma (GBM) causes poor survival in patients even when applying aggressive
treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for GBM treatment …

Convex non-negative matrix factorization for brain tumor delimitation from MRSI data

S Ortega-Martorell, PJG Lisboa, A Vellido, RV Simões… - 2012 - journals.plos.org
Background Pattern Recognition techniques can provide invaluable insights in the field of
neuro-oncology. This is because the clinical analysis of brain tumors requires the use of non …

Applications of high‐resolution magic angle spinning MRS in biomedical studies I—cell line and animal models

E Kaebisch, TL Fuss, LA Vandergrift… - NMR in …, 2017 - Wiley Online Library
High‐resolution magic angle spinning (HRMAS) MRS allows for direct measurements of non‐
liquid tissue and cell specimens to present valuable insights into the cellular metabolisms of …