Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …

Importance Early-onset atrial fibrillation (AF) can be the initial manifestation of a more
serious underlying inherited cardiomyopathy or arrhythmia syndrome. Objective To examine …

Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …

Transcriptional enhancers direct precise on-off patterns of gene expression during
development. To explore the basis for this precision, we conducted a high-throughput …

A small set of core transcription factors (TFs) dominates control of the gene expression
program in embryonic stem cells and other well-studied cellular models. These core TFs …

Transcription factors (TFs) are thought to function with partners to achieve specificity and
precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as …

Background: BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …

Variants in SCN10A, which encodes a voltage-gated sodium channel, are associated with
alterations of cardiac conduction parameters and the cardiac rhythm disorder Brugada …