Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C Xie, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

The urgent need to develop novel strategies for the diagnosis and treatment of snakebites

HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …

Old World Vipers—a review about snake venom proteomics of Viperinae and their variations

M Damm, BF Hempel, RD Süssmuth - Toxins, 2021 - mdpi.com
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease

HF Williams, BA Mellows, R Mitchell… - PLoS Neglected …, 2019 - journals.plos.org
Snakebite is a major neglected tropical health issue that affects over 5 million people
worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year …

Practical context of enzymatic treatment for wound healing: A secreted protease approach

M Isabela Avila-Rodríguez… - Biomedical …, 2020 - spandidos-publications.com
Skin wounds have been extensively studied as their healing represents a critical step
towards achieving homeostasis following a traumatic event. Dependent on the severity of …

[HTML][HTML] Biomedical applications of snake venom: From basic science to autoimmunity and rheumatology

CA Cañas, S Castaño-Valencia… - Journal of translational …, 2021 - Elsevier
Snake venoms have components with diverse biological actions that are extensively studied
to identify elements that may be useful in biomedical sciences. In the field of autoimmunity …

PI metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis

SK Bhat, MB Joshi, S Vasishta, RN Jagadale… - Journal of Venomous …, 2021 - SciELO Brasil
Background: Snake venoms are composed of pharmacologically active proteins that are
evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as …

Functional Mining of the Crotalus Spp. Venom Protease Repertoire Reveals Potential for Chronic Wound Therapeutics

D Meléndez-Martínez, LF Plenge-Tellechea… - Molecules, 2020 - mdpi.com
Chronic wounds are a major health problem that cause millions of dollars in expenses every
year. Among all the treatments used, active wound treatments such as enzymatic treatments …

Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain

BC Zychar, PB Clissa, E Carvalho, C Baldo… - Biochemical and …, 2020 - Elsevier
Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory
reactions after snakebites. This study aimed to investigate the effect of SVMP domains on …

The role of snake venom disintegrins in Angiogenesis

PB Clissa, MS Della-Casa, BC Zychar, SS Sanabani - Toxins, 2024 - mdpi.com
Angiogenesis, the formation of new blood vessels, plays a critical role in various
physiological and pathological conditions. Snake venom disintegrins (SVDs) have been …