Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
The urgent need to develop novel strategies for the diagnosis and treatment of snakebites
HF Williams, HJ Layfield, T Vallance, K Patel… - Toxins, 2019 - mdpi.com
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills in excess of
100,000 people per year. Additionally, many millions of survivors also suffer through …
100,000 people per year. Additionally, many millions of survivors also suffer through …
Old World Vipers—a review about snake venom proteomics of Viperinae and their variations
Fine-tuned by millions of years of evolution, snake venoms have frightened but also
fascinated humanity and nowadays they constitute potential resources for drug …
fascinated humanity and nowadays they constitute potential resources for drug …
Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease
HF Williams, BA Mellows, R Mitchell… - PLoS Neglected …, 2019 - journals.plos.org
Snakebite is a major neglected tropical health issue that affects over 5 million people
worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year …
worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year …
Practical context of enzymatic treatment for wound healing: A secreted protease approach
M Isabela Avila-Rodríguez… - Biomedical …, 2020 - spandidos-publications.com
Skin wounds have been extensively studied as their healing represents a critical step
towards achieving homeostasis following a traumatic event. Dependent on the severity of …
towards achieving homeostasis following a traumatic event. Dependent on the severity of …
[HTML][HTML] Biomedical applications of snake venom: From basic science to autoimmunity and rheumatology
CA Cañas, S Castaño-Valencia… - Journal of translational …, 2021 - Elsevier
Snake venoms have components with diverse biological actions that are extensively studied
to identify elements that may be useful in biomedical sciences. In the field of autoimmunity …
to identify elements that may be useful in biomedical sciences. In the field of autoimmunity …
PI metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis
Background: Snake venoms are composed of pharmacologically active proteins that are
evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as …
evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as …
Functional Mining of the Crotalus Spp. Venom Protease Repertoire Reveals Potential for Chronic Wound Therapeutics
D Meléndez-Martínez, LF Plenge-Tellechea… - Molecules, 2020 - mdpi.com
Chronic wounds are a major health problem that cause millions of dollars in expenses every
year. Among all the treatments used, active wound treatments such as enzymatic treatments …
year. Among all the treatments used, active wound treatments such as enzymatic treatments …
Leukocyte recruitment induced by snake venom metalloproteinases: Role of the catalytic domain
Snake venom metalloproteinases (SVMPs) are key toxins involved in local inflammatory
reactions after snakebites. This study aimed to investigate the effect of SVMP domains on …
reactions after snakebites. This study aimed to investigate the effect of SVMP domains on …
The role of snake venom disintegrins in Angiogenesis
Angiogenesis, the formation of new blood vessels, plays a critical role in various
physiological and pathological conditions. Snake venom disintegrins (SVDs) have been …
physiological and pathological conditions. Snake venom disintegrins (SVDs) have been …