Neurological and mental illnesses account for a considerable proportion of the global
burden of disease. Exercise has many beneficial effects on brain health, contributing to …

Despite strong scientific evidence supporting the benefits of regular exercise for the
prevention and management of cardiovascular disease (CVD), physical inactivity is highly …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …

A wide array of molecular pathways has been investigated during the past decade in order
to understand the mechanisms by which the practice of physical exercise promotes …

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Irisin is a myokine that leads to increased energy expenditure by stimulating the'browning'of
white adipose tissue. In the first description of this hormone, increased levels of circulating …

White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …